Affiliations
Member of the American Society for Mass Spectrometry (ASMS)
Senior Research Associate –
Dr. Meghan McFadden has been working with the Gramolini Lab since 2017.
Education and Professional Experience
Senior Research Associate (2017 – Present)
Proteomics, Ted Rogers Center for Heart Research, University of Toronto, Toronto, ON.
Mass Spectrometry Technician (2015-2017)
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON.
Research Associate (2015)
Biointerfaces Institute, McMaster University, Hamilton, ON.
Research Assistant (2014)
Department of Biochemistry, McMaster University, Hamilton, ON.
Chemistry Lecturer (2007 – Present)
PREP101
Ph.D. in Bioanalytical Chemistry
Department of Chemistry and Chemical Biology, McMaster University, Hamilton, ON.
Master of Science in Forensic Science
John Jay College of Criminal Justice, City University of New York, NY.
Bachelor of Science in Forensic Science and Psychology
University of Toronto, Toronto, ON.
Selected Publications
Myocardial Infarction Induces Cardiac Fibroblast Transformation within Injured and Noninjured Regions of the Mouse Heart
Shah, H., Hacker, A., Langburt, D., Dewar, M., McFadden, M.J., Zhang, H., Kuzmanov, U., Zhou, YQ., Hussain, B., Ehsan, F., Hinz, B., Gramolini, A.O., and Heximer, S.P. (2021). Myocardial infarction induces cardiac fibroblast transformation within injured and noninjured regions of the mouse heart. Journal of Proteome Research, 20, 2867-2881.
Proteome analysis of secretions from human monocyte-derived macrophages post-exposure to biomaterials and the effect of secretions on cardiac fibroblast fibrotic character
Shrestha, S., McFadden, M.J., Gramolini, A.O., and Santerre, J.P. (2020). Proteome analysis of secretions from human monocyte-derived macrophages post-exposure to biomaterials and the effect of secretions on cardiac fibroblast fibrotic character. Acta Biomaterialia, 111, 80-90.
Mapping signalling perturbations in myocardial fibrosis via the integrative phosphoproteomic profiling of tissue from diverse sources
Kuzmanov, U., Wang, E.Y., Vanderlaan, R., Kim, D.H., Lee, SH., Hadipour-Lakmehsari, S., Guo, H., Zhao, Y., McFadden, M., Sharma, P., Billia, F., Radisic, M., Gramolini, A., and Emili, A. (2020). Mapping signallng perturbations in myocardial fibrosis via the integrative phosphoproteomic profiling of tissue from diverse sources. Nature Biomedical Engineering, 4, 889-900.
Evaluation of the Calmodulin‐SOX9 Interaction by “Magnetic Fishing” Coupled to Mass Spectrometry
McFadden, M.J., Hryciw, T., Brown, A., Junop, M.S., and Brennan, J.D. (2014). Evaluation of the calmodulin-SOX9 interaction by magnetic “fishing” coupled to mass spectrometry. ChemBioChem, 15, 2411-2419.
Delineation of key XRCC4/Ligase IV interfaces for targeted disruption of non‐homologous end joining DNA repair
McFadden, M.J., Lee, W., Brennan, J.D., and Junop, M.S. (2014). Delineation of the key XRCC4- Ligase IV interface for targeted disruption of non-homologous end joining DNA repair. Proteins, 82, 187-194.
Magnetic “Fishing” Assay To Screen Small-Molecule Mixtures for Modulators of Protein−Protein Interactions
McFadden, M.J., Junop, M.S., and Brennan, J.D. (2010). Magnetic “fishing” assay to screen small molecule mixtures for modulators of protein-protein interactions. Analytical Chemistry, 82, 9850-9857.
Gramolini Lab 